Bruce Pike
Professor, Department of Neurology and Neurosurgery
Director, McConnell Brain Imaging Centre
McGill University
McConnell Brain Imaging Centre, 3801 University St,. #WB-315,
tel: 514-398-1929
e-mail: bruce(at)bic.mni.mcgill.ca
Membership Status
Associate Member
Research Themes
Areas of Expertise
My research is focused on MRI methods and applications for basic and clinical neuroscience. My primary focus, has been the detection and measurement of the physiological modulations that are involved in neuronal activation. This technique is called functional MRI (fMRI). fMRI can detect changes in blood oxygenation and tissue perfusion with a high temporal and spatial resolution. It also provides a powerful tool for studying activation physiology (e.g. flow / metabolism coupling). I also study quantitative MRI techniques such as magnetization transfer (MT) imaging. This technique probes the magnetic interaction between protons associated with macromolecules and water. MT imaging has many applications and the one that we have studied the most is multiple sclerosis
Current Research Interests
- Functional Magnetic Resonance Imaging (fMRI) of Brain Physiology
- fMRI Applications in Basic and Clincial Neuroscience
- Quantitative Magnetization Transfer (qMT) MRI Methods
- qMT in Multiple Sclerosis
- Anatomical and Functional MRI Simultaion and Optimization
- Normal Brain Development Characterization via MRI
- Diffusion Tensor Imaging (DTI) and White Matter Fibre Tracking
Selected Publications
- Sled, J.G & Pike, G,B. (2000). Quantitative interpretation of magnetization transfer in spoiled gradient echo MRI sequences. Journal of Magnetic Resonance, Jul;145(1), 24-36.
- Dumoulin, S.O., Bittar, R.G., Kabani, N.J., Baker, C.L. Jr., Le Goualher, G., Pike B.G. & Evans, A.C. (2000). A new anatomical landmark for reliable identification of human area V5/MT: a quantitative analysis of sulcal patterning. Cerebral Cortex, May;10(5), 454-63.
- Belin P., Zatorre, R.J., Lafaille, P., Ahad, P. & Pike, B. (2000). Voice-selective areas in human auditory cortex. Nature, Jan 20;403(6767), 309-12.
- Belin, P., Zatorre, R.J., Hoge, R,, Evans, A.C. & Pike, B. (1999). Event-related fMRI of the auditory cortex. Neuroimage, Oct;10(4), 417-29.
